Measurements of the Oxidation State of Manganese inside Brain, Heart, and Liver Mitochondria using XANES Spectroscopy
نویسندگان
چکیده
Most intracellular Mn is found in mitochondria. We have used the shift in the manganese absorption edge in x-ray absorption near edge structure (XANES) spectroscopy to determine the oxidation state of Mn in brain, heart, and liver mitochondria, as well as in PC12 cells. We compared the XANES spectra of Mn in brain, heart, and liver mitochondria over a range of Mn concentrations with those of Mn standards and over a range of conditions selected to increase ROS and Mn(III) production.
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